Journal article
The search for the MEN1 gene
I Lemmes, WJM Van De Ven, K Kas, CX Zhang, S Giraud, V Wautot, N Buisson, M Pugeat, JL Peix, A Caldener, F Parente, D Quincey, A Courseaux, GF Carle, P Gaudray, MJ De Wit, CJM Lips, JWM Höppener, S Khodaei, AL Grant Show all
Journal of Internal Medicine | WILEY | Published : 1998
Abstract
The search for the gene whose mutations predispose individuals to multiple endocrine neoplasia type 1 (MEN-1) started in 1988 when the MEN1 locus was assigned to 11q13, close to PYGM. It came to an end with the recent identification of a gene expressed ubiquitously which harbours inactivating mutations associated with MEN-1. During these nine years, the genetic linkage interval had been slowly reduced, and losses of heterozygosity (LOH) in MEN- 1 tumours had given strong indications that MEN1 was a tumour suppressor gene. It is ironic that MEN1 was finally found to be located less than 100 kb telomeric to PYGM. From the beginning, this gene was the most tightly linked genetically to MEN-1. I..
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