Antimicrobial profile of some novel keto esters: Synthesis, crystal structures and structure-activity relationship studies
Imtiaz Khan, Aamer Saeed, Mohammad Ifzan Arshad, Jonathan Michael White
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES | UNIV KARACHI | Published : 2016
Rapid increase in bacterial resistance has become a major public concern by escalating alongside a lack of development of new anti-infective drugs. Novel remedies in the battle against multidrug-resistant bacterial strains are urgently needed. So, in this context, the present work is towards the investigation of antimicrobial efficacy of some novel keto ester derivatives, which are prepared by the condensation of substituted benzoic acids with various substituted phenacyl bromides in dimethylformamide at room temperature using triethylamine as a catalyst. The structural build-up of the target compounds was accomplished by spectroscopic techniques including FTIR, (1)H and (13)C NMR spectrosco..View full abstract
Financial support from Higher Education Commission of Pakistan is gratefully acknowledged.