Journal article

Noninvasive prenatal testing in routine clinical practice - An audit of NIPT and combined first-trimester screening in an unselected Australian population

Andrew McLennan, Ricardo Palma-Dias, Fabricio Da Silva Costa, Simon Meagher, Debbie L Nisbet, Fergus Scott

AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY | WILEY | Published : 2016

Abstract

BACKGROUND: There are limited data regarding noninvasive prenatal testing (NIPT) in low-risk populations, and the ideal aneuploidy screening model for a pregnant population has yet to be established. AIMS: To assess the implementation of NIPT into clinical practice utilising both first- and second-line screening models. MATERIALS AND METHODS: Three private practices specialising in obstetric ultrasound and prenatal diagnosis in Australia offered NIPT as a first-line test, ideally followed by combined first-trimester screening (cFTS), or as a second-line test following cFTS, particularly in those with a calculated risk between 1:50 and 1:1000. RESULTS: NIPT screening was performed in 5267 wom..

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