Maternal-foetal transfer of Plasmodium falciparum and Plasmodium vivax antibodies in a low transmission setting
SC Charnaud, R McGready, A Herten-Crabb, R Powell, A Guy, C Langer, JS Richards, PR Gilson, K Chotivanich, T Tsuboi, DL Narum, M Pimanpanarak, JA Simpson, JG Beeson, F Nosten, FJI Fowkes
SCIENTIFIC REPORTS | NATURE PUBLISHING GROUP | Published : 2016
During pregnancy immunoglobulin G (IgG) antibodies are transferred from mother to neonate across the placenta. Studies in high transmission areas have shown transfer of P. falciparum-specific IgG, but the extent and factors influencing maternal-foetal transfer in low transmission areas co-endemic for both P. falciparum and P. vivax are unknown. Pregnant women were screened weekly for Plasmodium infection. Mother-neonate paired serum samples at delivery were tested for IgG to antigens from P. falciparum, P. vivax and other infectious diseases. Antibodies to malarial and non-malarial antigens were highly correlated between maternal and neonatal samples (median [range] spearman ρ = 0.78 [0.57-0..View full abstract
Awarded by National Health and Medical Research Council of Australia
We thank Julia McGuire for initial analyses. We thank Joe Smith for DBL5 and DBL-alpha antigens, Robin Anders for MSP2 antigen and Annie Mo for EBA175 antigen. This work was supported by the National Health and Medical Research Council of Australia (project grant 1049213, fellowships to FJIF and JGB, Infrastructure for Research Institutes Support Scheme Grant), Australian Research Council (Future Fellowship to FJIF and JGB), and Victorian State Government Operational Infrastructure Support grant. This research was supported in part by the Intramural Research Program of the NIH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.