Journal article
Intra-articular injection of photo-activated platelet-rich plasma in patients with knee osteoarthritis: A double-blind, randomized controlled pilot study
KL Paterson, M Nicholls, KL Bennell, D Bates
BMC Musculoskeletal Disorders | Published : 2016
Abstract
Background: Improvements in knee osteoarthritis (OA) symptoms with platelet-rich plasma (PRP) have been attributed to its ability to modify intra-articular inflammatory processes. Photo-activation of peripheral blood also improves inflammatory mediators associated with OA, however combined photo-activated PRP (PA-PRP) has not been investigated. This pilot study assessed the feasibility, safety and symptomatic and functional change following injections of PA-PRP compared to hyaluronic acid (HA) in people with knee osteoarthritis (OA). Methods: Thirty seven people with knee OA were enrolled in this double-blind randomized controlled pilot study set in a sports medicine clinic. Participants wer..
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Awarded by Australian Research Council
Funding Acknowledgements
The authors would like to thank Emma Eggleston for her valuable assistance in participant recruitment and in group allocation and concealment of the interventions. KLB is partially supported by Australian Research Council Future Fellowship (FTFT0991413). The Adilight-1 used for photo-activation was provided in-kind by AdiStem Ltd. The funders played no role in the design, data collection and analysis, decision to publish or preparation of the manuscript. KLB receives royalties from the sales of an educational osteoarthritis DVD and sales of an osteoarthritis shoe, neither of which are related to the work contained in this manuscript.