Retinal ganglion cells: mechanisms underlying depolarization block and differential responses to high frequency electrical stimulation of ON and OFF cells

T Kameneva; MI Maturana; AE Hadjinicolaou; SL Cloherty; MR Ibbotson; DB Grayden; AN Burkitt; H Meffin

Journal article

Retinal ganglion cells: mechanisms underlying depolarization block and differential responses to high frequency electrical stimulation of ON and OFF cells

T Kameneva, MI Maturana, AE Hadjinicolaou, SL Cloherty, MR Ibbotson, DB Grayden, AN Burkitt, H Meffin

JOURNAL OF NEURAL ENGINEERING | IOP PUBLISHING LTD | Published : 2016

DOI: 10.1088/1741-2560/13/1/016017

Abstract

OBJECTIVE: ON and OFF retinal ganglion cells (RGCs) are known to have non-monotonic responses to increasing amplitudes of high frequency (2 kHz) biphasic electrical stimulation. That is, an increase in stimulation amplitude causes an increase in the cell's spike rate up to a peak value above which further increases in stimulation amplitude cause the cell to decrease its activity. The peak response for ON and OFF cells occurs at different stimulation amplitudes, which allows differential stimulation of these functional cell types. In this study, we investigate the mechanisms underlying the non-monotonic responses of ON and OFF brisk-transient RGCs and the mechanisms underlying their different..

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University of Melbourne Researchers

Matias Maturana Author Medicine - St Vincent's Hospital

Hamish Meffin Author Biomedical Engineering

Tania Kameneva Author

David Grayden Author Biomedical Engineering

Michael Ibbotson Author Optometry and Vision Sciences

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Grants

Awarded by Australian Research Council

Awarded by ARC Centre of Excellence for Integrative Brain Function

Funding Acknowledgements

This research was supported by the Australian Research Council through Discovery Grants DE120102210, DP140104533, and Special Research Initiative (SRI) in Bionic Vision Science and Technology grant to Bionic Vision Australia(BVA). HM and MI acknowledge the support of the ARC Centre of Excellence for Integrative Brain Function (CE140100007).