Clioquinol Improves Cognitive, Motor Function, and Microanatomy of the Alpha-Synuclein hA53T Transgenic Mice

David I Finkelstein; Dominic J Hare; Jessica L Billings; Amelia Sedjahtera; Milawaty Nurjono; Elisa Arthofer; Sonia George; Janetta G Culvenor; Ashley I Bush; Paul A Adlard

Journal article

Clioquinol Improves Cognitive, Motor Function, and Microanatomy of the Alpha-Synuclein hA53T Transgenic Mice

David I Finkelstein, Dominic J Hare, Jessica L Billings, Amelia Sedjahtera, Milawaty Nurjono, Elisa Arthofer, Sonia George, Janetta G Culvenor, Ashley I Bush, Paul A Adlard

ACS CHEMICAL NEUROSCIENCE | AMER CHEMICAL SOC | Published : 2016

DOI: 10.1021/acschemneuro.5b00253

Abstract

The abnormal accumulation of alpha-synuclein (α-syn) has been linked to a number of neurodegenerative disorders, the most noteworthy of which is Parkinson's disease. Alpha-synuclein itself is not toxic and fulfills various physiological roles in the central nervous system. However, specific types of aggregates have been shown to be toxic, and metals have been linked to the assembly of these toxic aggregates. In this paper, we have characterized a transgenic mouse that overexpresses the A53T mutation of human α-syn, specifically assessing cognition, motor performance, and subtle anatomical markers that have all been observed in synucleinopathies in humans. We hypothesized that treatment with ..

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University of Melbourne Researchers

David Finkelstein Author

Dominic Hare Author

Jessica Billings Author

Ashley Bush Author

Grants

Funding Acknowledgements

P.A.A., A.I.B., and D.I.F. are supported by funds from the National Health and Medical Research Council and the Australian Research Council. The Florey Institute of Neuroscience and Mental Health acknowledge the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant.