Journal article
Blimp-1-Dependent IL-10 Production by Tr1 Cells Regulates TNF-Mediated Tissue Pathology
M Montes de Oca, R Kumar, F de Labastida Rivera, FH Amante, M Sheel, RJ Faleiro, PT Bunn, SE Best, L Beattie, SS Ng, CL Edwards, W Muller, E Cretney, SL Nutt, MJ Smyth, A Haque, GR Hill, S Sundar, A Kallies, CR Engwerda
Plos Pathogens | Published : 2016
Open access
Abstract
Tumor necrosis factor (TNF) is critical for controlling many intracellular infections, but can also contribute to inflammation. It can promote the destruction of important cell populations and trigger dramatic tissue remodeling following establishment of chronic disease. Therefore, a better understanding of TNF regulation is needed to allow pathogen control without causing or exacerbating disease. IL-10 is an important regulatory cytokine with broad activities, including the suppression of inflammation. IL-10 is produced by different immune cells; however, its regulation and function appears to be cell-specific and context-dependent. Recently, IL-10 produced by Th1 (Tr1) cells was shown to p..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
This work was made possible through Queensland State Government Funding, Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIIS. Research was supported by grants and Fellowships from the National Health and Medical Research Council of Australia, funding from the Australia-India Strategic Research fund made available by the Australian government Department of Innovation, Industry, Science and Research and Indian Government Department of Biotechnology, and core equipment funded by the Australian Cancer Research Foundation. RK is supported by INSPIRE Fellowship, Department of Science and Technology, Indian Government. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.