DNA methylation and the social gradient of osteoporotic fracture: A conceptual model

Sharon L Brennan-Olsen; Richard S Page; Michael Berk; Jose A Riancho; William D Leslie; Scott G Wilson; Karen L Saban; Linda Janusek; Julie A Pasco; Jason M Hodge; Shae E Quirk; Natalie K Hyde; Sarah M Hosking; Lana J Williams

Journal article

DNA methylation and the social gradient of osteoporotic fracture: A conceptual model

Sharon L Brennan-Olsen, Richard S Page, Michael Berk, Jose A Riancho, William D Leslie, Scott G Wilson, Karen L Saban, Linda Janusek, Julie A Pasco, Jason M Hodge, Shae E Quirk, Natalie K Hyde, Sarah M Hosking, Lana J Williams

BONE | ELSEVIER SCIENCE INC | Published : 2016

DOI: 10.1016/j.bone.2015.12.015

Abstract

INTRODUCTION: Although there is a documented social gradient for osteoporosis, the underlying mechanism(s) for that gradient remain unknown. We propose a conceptual model based upon the allostatic load theory, to suggest how DNA methylation (DNAm) might underpin the social gradient in osteoporosis and fracture. We hypothesise that social disadvantage is associated with priming of inflammatory pathways mediated by epigenetic modification that leads to an enhanced state of inflammatory reactivity and oxidative stress, and thus places socially disadvantaged individuals at greater risk of osteoporotic fracture. METHODS/RESULTS: Based on a review of the literature, we present a conceptual model i..

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University of Melbourne Researchers

Jason Hodge Author

Julie Pasco Author

Michael Berk Author Psychiatry

Sharon Brennan-Olsen Author

Related Projects (1)

MULTIDISCIPLINARY TRANSLATIONAL RESEARCH TO ADDRESS SOCIAL DISPARITIES IN OSTEOPOROSIS: UNDERSTANDING THE SOCIAL CONTEXT OF BIOLOGICAL MECHANISMS

Osteoporosis (OP) prevalence is greater for disadvantaged groups, as are less healthy lifestyles. Whilst reasons for this social gradient of..

Grants

Awarded by Institute de Salud Carlos III

Awarded by NHMRC Senior Principal Research Fellowship

Awarded by NHMRC Public Health and Health Services Research Postgraduate Scholarship

Awarded by NHMRC

Funding Acknowledgements

SLB-O is supported by an Alfred Deakin Postdoctoral Fellowship (2015-16). JAR is supported by Institute de Salud Carlos III (PI12/615). LJW is supported by a National Health and Medical Research Council (NHMRC of Australia) Career Development Fellowship (2015-18). NKH is supported by an Australian Postgraduate Award, Deakin University (2013-16). MB is supported by a NHMRC Senior Principal Research Fellowship (1059660). SEQ is supported by a NHMRC Public Health and Health Services Research Postgraduate Scholarship (1076347, 2013-15). This work is supported by the NHMRC (project grants 1048216, 1087407) and a Seeding Grant that was awarded to SLB-O by the IMPACT Strategic Research Centre, Deakin University (2015).