Journal article

DNA methylation and the social gradient of osteoporotic fracture: A conceptual model

Sharon L Brennan-Olsen, Richard S Page, Michael Berk, Jose A Riancho, William D Leslie, Scott G Wilson, Karen L Saban, Linda Janusek, Julie A Pasco, Jason M Hodge, Shae E Quirk, Natalie K Hyde, Sarah M Hosking, Lana J Williams

BONE | ELSEVIER SCIENCE INC | Published : 2016

Abstract

INTRODUCTION: Although there is a documented social gradient for osteoporosis, the underlying mechanism(s) for that gradient remain unknown. We propose a conceptual model based upon the allostatic load theory, to suggest how DNA methylation (DNAm) might underpin the social gradient in osteoporosis and fracture. We hypothesise that social disadvantage is associated with priming of inflammatory pathways mediated by epigenetic modification that leads to an enhanced state of inflammatory reactivity and oxidative stress, and thus places socially disadvantaged individuals at greater risk of osteoporotic fracture. METHODS/RESULTS: Based on a review of the literature, we present a conceptual model i..

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Grants

Awarded by Institute de Salud Carlos III


Awarded by NHMRC Senior Principal Research Fellowship


Awarded by NHMRC Public Health and Health Services Research Postgraduate Scholarship


Awarded by NHMRC


Funding Acknowledgements

SLB-O is supported by an Alfred Deakin Postdoctoral Fellowship (2015-16). JAR is supported by Institute de Salud Carlos III (PI12/615). LJW is supported by a National Health and Medical Research Council (NHMRC of Australia) Career Development Fellowship (2015-18). NKH is supported by an Australian Postgraduate Award, Deakin University (2013-16). MB is supported by a NHMRC Senior Principal Research Fellowship (1059660). SEQ is supported by a NHMRC Public Health and Health Services Research Postgraduate Scholarship (1076347, 2013-15). This work is supported by the NHMRC (project grants 1048216, 1087407) and a Seeding Grant that was awarded to SLB-O by the IMPACT Strategic Research Centre, Deakin University (2015).