Journal article

Predicting Disease Severity and Viral Spread of H5N1 Influenza Virus in Ferrets in the Context of Natural Exposure Routes

Kathryn M Edenborough, Suzanne Lowther, Karen Laurie, Manabu Yamada, Fenella Long, John Bingham, Jean Payne, Jennifer Harper, Jessica Haining, Rachel Arkinstall, Brad Gilbertson, Deborah Middleton, Lorena E Brown

JOURNAL OF VIROLOGY | AMER SOC MICROBIOLOGY | Published : 2016

Abstract

UNLABELLED: Although avian H5N1 influenza virus has yet to develop the capacity for human-to-human spread, the severity of the rare cases of human infection has warranted intensive follow-up of potentially exposed individuals that may require antiviral prophylaxis. For countries where antiviral drugs are limited, the World Health Organization (WHO) has developed a risk categorization for different levels of exposure to environmental, poultry, or human sources of infection. While these take into account the infection source, they do not account for the likely mode of virus entry that the individual may have experienced from that source and how this could affect the disease outcome. Knowledge ..

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