Journal article

Consistent topography and amplitude symmetry are more typical than morphology of epileptiform discharges in genetic generalized epilepsy

Udaya Seneviratne, Mark Cook, Wendyl D'Souza

CLINICAL NEUROPHYSIOLOGY | ELSEVIER IRELAND LTD | Published : 2016

Abstract

OBJECTIVE: To provide a quantitative evaluation of typical electroencephalographic (EEG) abnormalities in genetic generalized epilepsy (GGE). METHODS: We prospectively performed 24-h ambulatory EEG recordings in a cohort of patients with GGE. The diagnosis was established according to the International League Against Epilepsy criteria. Details of all epileptiform discharges across the 24-h time scale were entered into an electronic database. We carried out descriptive statistics to provide a quantitative breakdown of typical EEG abnormalities. RESULTS: A total of 6923 epileptiform discharges from 105 abnormal 24-h ambulatory EEGs were analyzed. 96% of discharges were symmetric in amplitude w..

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