Consistent topography and amplitude symmetry are more typical than morphology of epileptiform discharges in genetic generalized epilepsy

Abstract

Objective: To provide a quantitative evaluation of typical electroencephalographic (EEG) abnormalities in genetic generalized epilepsy (GGE). Methods: We prospectively performed 24-ambulatory EEG recordings in a cohort of patients with GGE. The diagnosis was established according to the International League Against Epilepsy criteria. Details of all epileptiform discharges across the 24-time scale were entered into an electronic database. We carried out descriptive statistics to provide a quantitative breakdown of typical EEG abnormalities. Results: A total of 6923 epileptiform discharges from 105 abnormal 24-ambulatory EEGs were analyzed. 96% of discharges were symmetric in amplitude with fr..