Innate lymphoid cells: parallel checkpoints and coordinate interactions with T cells
Nicholas D Huntington, Sabrina Carpentier, Eric Vivier, Gabrielle T Belz
CURRENT OPINION IN IMMUNOLOGY | CURRENT BIOLOGY LTD | Published : 2016
Protection of epithelial and mucosal surfaces is required for survival. The recent discovery of a diverse array of innate lymphoid cells that lie immediately beneath these surfaces has unexpectedly uncovered an entire defense system distinct from the adaptive system essential to protect these barriers. This multilayered design provides a robust system through coupling of two highly complementary networks to ensure immune protection. Here, we discuss the similarities in the hardwiring and diversification of innate lymphoid cells and T cells during mammalian immune responses.
Awarded by ANR
G.T.B. and N.H. laboratories are supported by grants and fellowships from the National Health and Medical Research Council (NHMRC) of Australia (G.T.B., N.H.) and the Australian Research Council (G.T.B.), the Victorian State Government Operational Infrastructure Support and the Australian Government NHMRC IRIIS. The EV laboratory is supported by the European Research Council (THINK Advanced Grant), the Ligue Nationale contre le Cancer (Equipe Labellisee) and by institutional grants from INSERM, CNRS and Aix-Marseille University to CIML. S.C. is partly funded by ANR grant no ANR-11-DPBS-0002. E.V. is a scholar of the Institut Universitaire de France.