Bone morphogenetic proteins in spinal surgery

GM Malham; GG Giles; RL Milne; CM Blecher; GA Brazenor

Journal article

Bone morphogenetic proteins in spinal surgery

GM Malham, GG Giles, RL Milne, CM Blecher, GA Brazenor

Spine | Published : 2015

DOI: 10.1097/BRS.0000000000001184

Abstract

Study Design. A retrospective cohort study. Objective. The aim of this study was to determine the fusion rate using recombinant human bone morphogenetic protein (rhBMP) in spinal surgery and to estimate the risk of cancer subsequent to their use. Summary of Background Data. rhBMP may obviate the need for iliac crest bone graft harvest and provides similar or higher fusion rates than autologous bone graft. Recently, there are concerns that rhBMPs may either cause cancer or accelerate progression. Methods. Patients were treated by 2 spine surgeons between 2002 and 2012. Inclusion criteria were patients who resided in the state of Victoria, Australia, undergoing lumbar fusion (anterior, lateral..

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University of Melbourne Researchers

Graham Giles Author

Roger Milne Author

Grants

Funding Acknowledgements

The devices/drugs are FDA-approved or approved by corresponding national agency for this indication (Australia: Therapeutic Goods Administration). Epworth Foundation funds were received in support of this work. Relevant financial activities outside the submitted work: travel/accommodations/meeting expenses.