Journal article

Ghrelin and motilin receptors as drug targets for gastrointestinal disorders

Gareth J Sanger, John B Furness

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY | NATURE PUBLISHING GROUP | Published : 2016

Abstract

The gastrointestinal tract is the major source of the related hormones ghrelin and motilin, which act on structurally similar G protein-coupled receptors. Nevertheless, selective receptor agonists are available. The primary roles of endogenous ghrelin and motilin in the digestive system are to increase appetite or hedonic eating (ghrelin) and initiate phase III of gastric migrating myoelectric complexes (motilin). Ghrelin and motilin also both inhibit nausea. In clinical trials, the motilin receptor agonist camicinal increased gastric emptying, but at lower doses reduced gastroparesis symptoms and improved appetite. Ghrelin receptor agonists have been trialled for the treatment of diabetic g..

View full abstract

University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by MRC


Awarded by Medical Research Council


Funding Acknowledgements

Work from the Queen Mary University of London laboratory is currently supported by the research into ageing fund, set up and managed by AgeUK, British Biotechnology Science Research Council, Dunhill Medical Trust, and Takeda Pharmaceuticals. Work from the University of Melbourne laboratory is supported by the National Health and Medical Research Council of Australia (project grant number 1079739) and the Transport Accident Commission, through the Institute for Safety, Compensation and Recovery Research.