Can mortality of cancer patients with fever and neutropenia be improved?
Karin A Thursky, Leon J Worth
CURRENT OPINION IN INFECTIOUS DISEASES | LIPPINCOTT WILLIAMS & WILKINS | Published : 2015
PURPOSE OF REVIEW: Neutropenic fever is the most common infective complication in patients receiving cytotoxic chemotherapy, and may result in severe sepsis, septic shock and mortality. Advancements in approaches to empiric antimicrobial therapy and prophylaxis have resulted in improved outcomes. Mortality may, however, still be as high as 50% in high-risk cancer populations. The objective of this review is to summarize factors associated with reduced mortality in patients with neutropenic fever, highlighting components of clinical care with potential for inclusion in quality improvement programs. RECENT FINDINGS: Risks for mortality are multifactorial, and include patient, disease and treat..View full abstract