Journal article

Antiepileptic Effects of Lacosamide Loaded Polymers Implanted Subdurally in GAERS

Sebastien H Bauquier, Jonathan L Jiang, Zhilian Yue, Alan Lai, Yu Chen, Simon E Moulton, Karen J McLean, Sara Vogrin, Amy J Halliday, Gordon Wallace, Mark J Cook



The current experiment investigated the ability of coaxial electrospun poly(D,L-lactide-co-glycolide) (PLGA) biodegradable polymer implants loaded with the antiepileptic drugs (AED) lacosamide to reduce seizures following implantation above the motor cortex in the Genetic Absence Epilepsy Rat from Strasbourg (GAERS). In this prospective, randomized, masked experiments, GAERS underwent surgery for implantation of skull electrodes (n = 6), skull electrodes and blank polymers (n = 6), or skull electrodes and lacosamide loaded polymers (n = 6). Thirty-minute electroencephalogram (EEG) recordings were started at day 7 after surgery and continued for eight weeks. The number of SWDs and mean durati..

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Funding Acknowledgements

The authors gratefully acknowledge the sponsorship of the Victorian Government through its Science Technology and Innovation Initiative administered by the Department of Industry, Innovation and Regional Development. The authors thank the Australian Research Council (ARC) for continuing financial support. Gordon Wallace thanks the ARC for his Laureate Fellowships. The authors also acknowledge use of the facilities and the assistance of Mr. Tony Romeo at the UOW Electron Microscopy Centre. The authors are grateful for access to materials synthesis and characterization equipment made available through the Australian National Fabrication Facility (ANFF).