Journal article
Image guidance protocol for synchrotron microbeam radiation therapy
D Pelliccia, CM Poole, J Livingstone, AW Stevenson, LML Smyth, PAW Rogers, D Haüsermann, JC Crosbie
Journal of Synchrotron Radiation | INT UNION CRYSTALLOGRAPHY | Published : 2016
Abstract
The protocol for image-guided microbeam radiotherapy (MRT) developed for the Australian Synchrotron's Imaging and Medical Beamline (IMBL) is described. The protocol has been designed for the small-animal MRT station of IMBL to enable future preclinical trials on rodents. The image guidance procedure allows for low-dose monochromatic imaging at 50 keV and subsequent semi-automated sample alignment in 3D with sub-100 mm accuracy. Following the alignment, a beamline operation mode change is performed and the relevant beamline components are automatically aligned for the treatment (pink) beam to be delivered on the sample. Here, the small-animalMRT station, the parameters and procedures for the ..
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Funding Acknowledgements
JFC acknowledges an Early Career Research Fellowship from the Australian National Health and Medical Research Council. We are grateful to F. Gagliardi for providing us with the PRESAGE dosimeters and to C. Hall for experimental assistance during the data acquisition. This research was undertaken on the Imaging and Medical Beamline at the Australian Synchrotron, Victoria, Australia