Journal article
Telomere dynamics during aging in polygenic left ventricular hypertrophy
FZ Marques, SA Booth, PR Prestes, CL Curl, LMD Delbridge, P Lewandowski, SB Harrap, FJ Charchar
Physiological Genomics | Published : 2016
Abstract
Short telomeres are associated with increased risk of cardiovascular disease. Here we studied cardiomyocyte telomere length at key ages during the ontogeny of cardiac hypertrophy and failure in the hypertrophic heart rat (HHR) and compared these with the normal heart rat (NHR) control strain. Key ages corresponded with the pathophysiological sequence beginning with fewer cardiomyocytes (2 days), leading to left ventricular hypertrophy (LVH) (13 wk) and subsequently progression to heart failure (38 wk). We measured telomere length, tissue activity of telomerase, mRNA levels of telomerase reverse transcriptase (Tert) and telomerase RNA component (Terc), and expression of the telomeric regulato..
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Grants
Awarded by National Health & Medical Research Council of Australia (NHMRC) Project
Awarded by National Heart Foundation
Awarded by NHMRC Grant
Funding Acknowledgements
This work was supported by National Health & Medical Research Council of Australia (NHMRC) Project Grant APP1034371, National Heart Foundation Grant G10M5155, and the Federation University Australia "Self-sustaining Regions Research and Innovation Initiative," an Australian Government Collaborative Research Network. S. A. Booth is supported by an Australian Postgraduate Award scholarship. F. Z. Marques is supported by NHMRC Grant APP1052659 and National Heart Foundation Grant PF12M6785 coshared Early Career Fellowships. P. R. Prestes is supported by a Robert HT Smith Fellowship from Federation University.