Journal article
FoxO3 suppresses Myc-driven lymphomagenesis
CJ Vandenberg, N Motoyama, S Cory
Cell Death and Disease | Published : 2016
Abstract
This study demonstrates, for the first time, that loss of a single forkhead box class O (FoxO) transcription factor, can promote lymphomagenesis. Using two different mouse models, we show that FoxO3 has a significant tumour-suppressor function in the context of Myc-driven lymphomagenesis. Loss of FoxO3 significantly accelerated myeloid tumorigenesis in vavP-MYC10 transgenic mice and B lymphomagenesis in Eμ-myc transgenic mice. Tumour analysis indicated that the selective pressure for mutation of the p53 pathway during Eμ-myc lymphomagenesis was not altered. Frank tumours were preceded by elevated macrophage numbers in FoxO3-/- vavP-MYC10 mice but, surprisingly, pre-B-cell numbers were relati..
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Awarded by National Cancer Institute
Funding Acknowledgements
We thank our institute colleagues A Strasser, MJ Herold and Steve Nutt for useful discussions; J Mansheim, K Hughes, S Allan, M Robati and J Corbin for excellent technical assistance; and the institute's Flow Cytometry Facility for skilled support. This work was supported by the NHMRC (Australia) program grants 461221; 1016647; NCI grant CA43540; Leukemia and Lymphoma Society Specialized Center for Research Grant 7015-02; an NHMRC Career Development Award (CJV); and infrastructure support to WEHI from the NHMRC Independent Research Institute Infrastructure Support Scheme (IRISS) and the Victorian State Government Operational Infrastructure Support (OIS).