Journal article

Defining Core and Penumbra in Ischemic Stroke: A Voxel- and Volume-Based Analysis of Whole Brain CT Perfusion

Yannan Yu, Quan Han, Xinfa Ding, Qingmeng Chen, Keqi Ye, Sheng Zhang, Shenqiang Yan, Bruce CV Campbell, Mark W Parsons, Shaoshi Wang, Min Lou



Whole brain computed tomography perfusion (CTP) has the potential to select eligible patients for reperfusion therapy. We aimed to find the optimal thresholds on baseline CTP for ischemic core and penumbra in acute ischemic stroke. We reviewed patients with acute ischemic stroke in the anterior circulation, who underwent baseline whole brain CTP, followed by intravenous thrombolysis and perfusion imaging at 24 hours. Patients were divided into those with major reperfusion (to define the ischemic core) and minimal reperfusion (to define the extent of penumbra). Receiver operating characteristic (ROC) analysis and volumetric consistency analysis were performed separately to determine the optim..

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Awarded by Science Technology Department of Zhejiang Province

Awarded by National Natural Science Foundation of China

Funding Acknowledgements

This study is a collaborative research with International Stroke Perfusion Imaging Registry (INSPIRE) program. Cases included and MIStar software are belong to INSPIRE program. MIStar was provided by Professor Mark Parsons, Australia. This work was supported by the Science Technology Department of Zhejiang Province (2013C03043-3) and the National Natural Science Foundation of China (81171095 & 81471170).