Plasmodium malariae Infection Associated with a High Burden of Anemia: A Hospital-Based Surveillance Study
Siobhan Langford, Nicholas M Douglas, Daniel A Lampah, Julie A Simpson, Enny Kenangalem, Paulus Sugiarto, Nicholas M Anstey, Jeanne Rini Poespoprodjo, Ric N Price
PLOS NEGLECTED TROPICAL DISEASES | PUBLIC LIBRARY SCIENCE | Published : 2015
BACKGROUND: Plasmodium malariae is a slow-growing parasite with a wide geographic distribution. Although generally regarded as a benign cause of malaria, it has been associated with nephrotic syndrome, particularly in young children, and can persist in the host for years. Morbidity associated with P. malariae infection has received relatively little attention, and the risk of P. malariae-associated nephrotic syndrome is unknown. METHODOLOGY/PRINCIPAL FINDINGS: We used data from a very large hospital-based surveillance system incorporating information on clinical diagnoses, blood cell parameters and treatment to describe the demographic distribution, morbidity and mortality associated with P...View full abstract
Awarded by Wellcome Trust
Awarded by NHMRC (National Health and Medical Research Council)
The Timika Research Facility and Papuan Community Health Foundation were supported by AusAID (Australian Agency for International Development, Department of Foreign Affairs and Trade - http://dfat.gov.au/aid/Pages/australias-aid-program.aspx). NMD was funded by the Rhodes Trust (http://www.rhodeshouse.ox.ac.uk/). The study was funded by the Wellcome Trust (Senior Fellowship in Clinical Science to RNP 091625 - http://www.wellcome.ac.uk/) and the NHMRC (National Health and Medical Research Council, Program Grant 1037304 to RNP and NMA - https://www.nhmrc.gov.au/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.