T helper 17 cells may drive neuroprogression in major depressive disorder: Proposal of an integrative model

A Slyepchenko; M Maes; CA Köhler; G Anderson; J Quevedo; GS Alves; M Berk; BS Fernandes; AF Carvalho

Journal article

T helper 17 cells may drive neuroprogression in major depressive disorder: Proposal of an integrative model

A Slyepchenko, M Maes, CA Köhler, G Anderson, J Quevedo, GS Alves, M Berk, BS Fernandes, AF Carvalho

Neuroscience and Biobehavioral Reviews | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2016

DOI: 10.1016/j.neubiorev.2016.02.002

Abstract

The exact pathophysiology of major depressive disorder (MDD) remains elusive. The monoamine theory, which hypothesizes that MDD emerges as a result of dysfunctional serotonergic, dopaminergic and noradrenergic pathways, has guided the therapy of this illness for several decades. More recently, the involvement of activated immune, oxidative and nitrosative stress pathways and of decreased levels of neurotrophic factors has provided emerging insights regarding the pathophysiology of MDD, leading to integrated theories emphasizing the complex interplay of these mechanisms that could lead to neuroprogression. In this review, we propose an integrative model suggesting that T helper 17 (Th17) cell..

View full abstract

University of Melbourne Researchers

Michael Berk Author

Grants

Awarded by Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University

Funding Acknowledgements

AFC and IQ are recipients of research fellowship awards from the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq; Brazil). CAK is the recipient of a postdoctoral fellowship award from CAPES (Brazil). GSA is supported by an international postdoctoral fellowship from CNPq (Brazil). MB is supported by an NHMRC Senior Principal Research Fellowship 1059660. The Laboratory of Neurosciences (Brazil) is one of the centers of the National Institute for Molecular Medicine (INCT-MM) and one of the members of the Center of Excellence in Applied Neurosciences of Santa Catarina (NENASC). This research was supported by grants from CNPq (IQ and AFC), FAPESC (JQ), Instituto Cerebro e Mente (JQ) and UNESC (JQ). The Center for Translational Psychiatry (USA) is funded by the Department of Psychiatry and Behavioral Sciences, The University of Texas Medical School at Houston.