Journal article
Affective instability and the course of bipolar depression: Results from the STEP-BD randomised controlled trial of psychosocial treatment
JP Stange, LG Sylvia, PV Da Silva Magalhães, DJ Miklowitz, MW Otto, E Frank, C Yim, M Berk, DD Dougherty, AA Nierenberg, T Deckersbach
British Journal of Psychiatry | Published : 2016
Abstract
Background: Little is known about predictors of recovery from bipolar depression. Aims: We investigated affective instability (a pattern of frequent and large mood shifts over time) as a predictor of recovery from episodes of bipolar depression and as a moderator of response to psychosocial treatment for acute depression. Method: A total of 252 out-patients with DSM-IV bipolar I or II disorder and who were depressed enrolled in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) and were randomised to one of three types of intensive psychotherapy for depression (n= 141) or a brief psychoeducational intervention (n =111). All analyses were by intention-to-treat. Result..
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Awarded by National Institutes of Health
Funding Acknowledgements
STEP-BD was funded in part by contract N01MH80001 from the National Institute of Mental Health (NIMH, Gary Sachs). Support for the development of the psychosocial treatments was provided by grants MH29618 (E.F.), MH43931 (D.J.M.) and MH55101 (D.J.M.) from the NIMH and by the National Alliance for Research on Schizophrenia and Depression (D.J.M.). J.S. was supported by National Research Service Award F31MH099761 from NIMH. L.G.S. received research support from NIMH (grant no. 1K23MH91182-1A1 and N01MH80001-01). D.J.M. has received research support from NIMH (grant no. HR01mh093676 and R33MH097007), Brain and Behavior Research Foundation, American Foundation of Suicide Prevention, Danny Alberts Foundation, Deutsch Foundation, Kayne Foundation, and Attias Family Foundation; M.B. is supported by a NHMRC Senior Principal Research Fellowship (1059660) and has received grant/research support from the NIH (grant no. 1R34MH091384-01A1), Cooperative Research Centre, Simons Autism Foundation, Cancer Council of Victoria, Stanley Medical Research Foundation, MBF, NHMRC, Beyond Blue, Rotary Health, Geelong Medical Research Foundation. T.D. was supported in part by a K-23 NIMH Career Award 1K23MH074895-01A2. His research has also been funded by NARSAD, TSA, OCF and Tufts University.