Journal article
Regulators of mitochondrial complex I activity: A review of literature and evaluation in postmortem prefrontal cortex from patients with bipolar disorder
A Duong, Y Che, D Ceylan, A Pinguelo, AC Andreazza, L Trevor Young, M Berk
Psychiatry Research | Published : 2016
Abstract
Phenomenologically, bipolar disorder (BD) is characterized by biphasic increases and decreases in energy. As this is a state-related phenomenon, identifying regulators responsible for this phasic dysregulation has the potential to uncover key elements in the pathophysiology of BD. Given the evidence suggesting mitochondrial complex I dysfunction in BD, we aimed to identify the main regulators of complex I in BD by reviewing the literature and using the published microarray data to examine their gene expression profiles. We also validated protein expression levels of the main complex I regulators by immunohistochemistry. Upon reviewing the literature, we found PARK-7, STAT-3, SIRT-3 and IMP-2..
View full abstractGrants
Awarded by Canadian Institutes of Health Research
Funding Acknowledgements
We thank the Stanley Medical Research Institute (SMRI)-Online Genomics Database and Elashoff Consulting, LLC for providing access to the public available microarray data. We also thank Dr. Sabine Bahn, Dr. Tadafumi Kato, Dr. Marquis P. Vawter, Dr. Trevor Young, Dr. Seth E. Dobrin, Dr. Haiming Chen, Dr. Allen A. Fienberg, Dr. Pamela Sklar collaborators from SMRI Online Genomics Database. MB is supported by a NHMRC Senior Principal Research Fellowship 1059660. ACA is supported by Canadian Institutes of Health Research (CIHR 133439), Ontario Mental Health Foundation (OMHF 498567) and Ministry of Research and Innovation of Canada. LTY is supported by CIHR 133439.