Immunity to malaria in an era of declining malaria transmission
Freya JI Fowkes, Philippe Boeuf, James G Beeson
PARASITOLOGY | CAMBRIDGE UNIV PRESS | Published : 2016
With increasing malaria control and goals of malaria elimination, many endemic areas are transitioning from high-to-low-to-no malaria transmission. Reductions in transmission will impact on the development of naturally acquired immunity to malaria, which develops after repeated exposure to Plasmodium spp. However, it is currently unclear how declining transmission and malaria exposure will affect the development and maintenance of naturally acquired immunity. Here we review the key processes which underpin this knowledge; the amount of Plasmodium spp. exposure required to generate effective immune responses, the longevity of antibody responses and the ability to mount an effective response u..View full abstract
This work was supported by the Australian Research Council (Future Fellowship to F. J. I. F.), the National Health and Medical Research Council of Australia (Senior Research Fellowship to J. G. B.), Infrastructure for Research Institutes Support Scheme Grant), and Victorian State Government Operational Infrastructure Support grant.