Journal article
Contrasting Patterns of Serologic and Functional Antibody Dynamics to Plasmodium falciparum Antigens in a Kenyan Birth Cohort
AE Dent, I Malhotra, X Wang, D Babineau, KT Yeo, T Anderson, RJ Kimmel, E Angov, DE Lanar, D Narum, S Dutta, J Richards, JG Beeson, BS Crabb, AF Cowman, T Horii, E Muchiri, PL Mungai, CL King, JW Kazura
Clinical and Vaccine Immunology | AMER SOC MICROBIOLOGY | Published : 2016
DOI: 10.1128/CVI.00452-15
Abstract
IgG antibodies to Plasmodium falciparum are transferred from the maternal to fetal circulation during pregnancy, wane after birth, and are subsequently acquired in response to natural infection. We examined the dynamics of malaria antibody responses of 84 Kenyan infants from birth to 36 months of age by (i) serology, (ii) variant surface antigen (VSA) assay, (iii) growth inhibitory activity (GIA), and (iv) invasion inhibition assays (IIA) specific for merozoite surface protein 1 (MSP1) and sialic acid-dependent invasion pathway. Maternal antibodies in each of these four categories were detected in cord blood and decreased to their lowest level by approximately 6 months of age. Serologic anti..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
HHS vertical bar NIH vertical bar National Institute of Allergy and Infectious Diseases (NIAID) provided funding to Arlene E. Dent under grant number AI098511. HHS vertical bar NIH vertical bar National Institute of Allergy and Infectious Diseases (NIAID) provided funding to Christopher L. King under grant number AI064667. HHS vertical bar NIH vertical bar National Institute of Allergy and Infectious Diseases (NIAID) provided funding to James W. Kazura under grant number AI09519.