Journal article

Experimental autoimmune gastritis: Mouse models of human organ-specific autoimmune disease

J Field, MA Biondo, K Murphy, F Alderuccio, BH Toh

INTERNATIONAL REVIEWS OF IMMUNOLOGY | TAYLOR & FRANCIS INC | Published : 2005

Abstract

Experimental autoimmune gastritis (EAG) is an excellent model of human autoimmune gastritis, the underlying cause of pernicious anaemia. Murine autoimmune gastritis replicates human gastritis in being characterized by a chronic inflammatory mononuclear cell infiltrate in the gastric mucosa, destruction of parietal and zymogenic cells, and autoantibodies to the alpha-and beta-subunits of the gastric H+/K+ ATPase. Disease is induced strain specifically in gastritis-susceptible BALB/c mice by methods with a greater variety than those for most other experimental autoimmune diseases. The disease is induced in the regional gastric lymph node in which pathogenic CD4+ T cells are recruited. The mode..

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University of Melbourne Researchers