Journal article

Prednisolone promotes remission and gastric mucosal regeneration in experimental autoimmune gastritis

M Biondo, J Field, B-H Toh, F Alderuccio

JOURNAL OF PATHOLOGY | WILEY | Published : 2006

Abstract

A cardinal feature of organ-specific autoimmunity is destructive pathology in the target organ. In human and experimental models of autoimmune gastritis, mononuclear cell infiltration and cellular destruction in the gastric mucosa are disease hallmarks. Strategies to cure autoimmune disease must not only establish immunological tolerance to autoantigen, but also rid the organ of pathogenic autoreactive cells. The present study has assessed the effect of prednisolone treatment in clearing the inflammatory infiltrate in experimental autoimmune gastritis and in preventing disease relapse in athymic compared with euthymic mice. Experimental autoimmune gastritis was induced by neonatal thymectomy..

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University of Melbourne Researchers