Plasma and human milk concentrations of moclobemide in nursing mothers

Abstract

Plasma and breast milk concentrations of the monoamine oxidase-A inhibitor, moclobemide were measured in eight women being treated for post-partum depression. The main milk to plasma ratio was 0.68, with a range of 0.39-1.21. There was no correlation between this ratio and dose of the drug. Based on the milk to plasma ratio, the infants were exposed to < 1% of the maternal dose. This exposure did not appear to have any adverse effects on the infants' developmental milestones as judged by clinical observation. Long term follow up of these children and further study of within day variations in plasma and breast milk moclobemide after chronic dosage are required.