Mild cognitive impairment can be detected by multiple assessments in a single day

Abstract

Background: Reliable detection of mild cognitive impairment (MCI), in many cases preceding AD, is important in determining the efficacy of emerging treatments. The operational definition of MCI is currently imprecise and would be improved by objective criteria. Inherent in the transition from MCI to AD is cognitive decline, which can be detected using multiple assessments over several years. Objective: To determine whether multiple assessments on the same day could also differentiate well-studied subjects with very mild MCI from normal control subjects. Methods: This study utilized a novel 15- to 18-minute computerized cognitive battery designed for frequent serial use, administered four tim..