Journal article

Evidence of persistent neurologic injury following thrombotic thrombocytopenic purpura

Spero R Cataland, Marie A Scully, James Paskavitz, Paul Maruff, Leslie Witkoff, Ming Jin, Nicholas Uva, James C Gilbert, Haifeng M Wu

AMERICAN JOURNAL OF HEMATOLOGY | WILEY | Published : 2011

Abstract

Despite improvements in our understanding of the pathophysiology of thrombotic thrombocytopenic purpura (TTP), little data exist regarding the long-term sequelae following a diagnosis of TTP. We present the results of a comprehensive evaluation of neurologic injury that included a magnetic resonance imaging (MRI), a neurocognitive testing, and an evaluation of health-related quality of life. Twenty-seven patients with a history of idiopathic TTP functioning normally in their activities of daily living were recruited from existing patient cohorts at both the Ohio State University (n 5 12) (Columbus) and the University College London Hospitals (n 5 15) (London, UK). Nine of 23 (39%) of the MRI..

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University of Melbourne Researchers