Cerebral function tests reveal differences in HIV-infected subjects with and without chronic HCV co-infection
A Thiyagarajan, LJ Garvey, H Pflugrad, P Maruff, G Scullard, J Main, S Taylor-Robsinson, A Winston
CLINICAL MICROBIOLOGY AND INFECTION | ELSEVIER SCI LTD | Published : 2010
Neurocognitive impairment (NCI) remains prevalent in HIV-infected subjects despite effective combination antiretroviral therapy (CART). In subjects without evidence of hepatic decompensation, NCI is also a feature of chronic HCV infection. The present study aimed to examine cerebral function and establish differences between HIV-HCV co-infected (HCVco) and HIV mono-infected (HIVmo) individuals. Neurologically asymptomatic subjects with chronic HCVco were eligible and underwent computerized neurocognitive testing (CogState; CogState Ltd, Melbourne, Australia), a dementia assessment [International HIV Dementia Scale (IHDS)] and memory assessment [the Prospective and Retrospective Memory Questi..View full abstract
We are grateful for support from the NIHR Biomedical Research Centre funding scheme. We would like to thank T. Chenhall (CogState Ltd, Melbourne, Australia) for advice regarding the analysis of the neurocognitive test results.