Journal article
Bacterial Biofilm Infection Detected in Breast Implant-Associated Anaplastic Large-Cell Lymphoma
H Hu, K Johani, A Almatroudi, K Vickery, B Van Natta, ME Kadin, G Brody, M Clemens, CY Cheah, S Lade, PA Joshi, HM Prince, AK Deva
Plastic and Reconstructive Surgery | Published : 2016
Abstract
Background: A recent association between breast implants and the development of anaplastic large-cell lymphoma (ALCL) has been observed. The purpose of this study was to identify whether bacterial biofilm is present in breast implant-associated ALCL and, if so, to compare the bacterial microbiome to nontumor capsule samples from breast implants with contracture. Methods: Twenty-six breast implant-associated ALCL samples were analyzed for the presence of biofilm by real-time quantitative polymerase chain reaction, next-generation sequencing, fluorescent in situ hybridization, and scanning electron microscopy, and compared to 62 nontumor capsule specimens. Results: Both the breast implant-asso..
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Funding Acknowledgements
The authors acknowledge Debra Birch, Microscopy Department, School of Biological Sciences, Macquarie University, for providing expertise in electron microscopy. The authors acknowledge Louis Wessels, M.B.ChB., M.Med., M.A.S., in compiling clinical data for non-tumor capsule patients. Karen Vickery, Ph.D., B.V.Sc., was in receipt of a Macquarie University Vice Chancellor Innovation Fellowship.