Journal article

THE BASEMENT-MEMBRANE ZONE OF THE NAIL

RD SINCLAIR, F WOJNAROWSKA, IM LEIGH, RPR DAWBER

BRITISH JOURNAL OF DERMATOLOGY | BLACKWELL SCIENCE LTD | Published : 1994

Abstract

The anatomy of the epidermis, dermis and subcutaneous tissues of the nail apparatus is distinct from that of non-appendageal skin. Apart from the demonstration of the longitudinal configuration of the dermal-epidermal junction of the nail bed, there have been no studies of the composition of the basement membrane zone of the nail apparatus. We obtained three human accessory digits, including one thumb, all of which had been amputated for cosmetic reasons, and were without known pathology. Specimens were stained with a battery of monoclonal and polyclonal antibodies which target normal basement membrane zone antigens, and studied by indirect immunofluorescence. This study demonstrated that th..

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