Journal article

Comparing Outcomes with Bone Marrow or Peripheral Blood Stem Cells as Graft Source for Matched Sibling Transplants in Severe Aplastic Anemia across Different Economic Regions

Rajat Kumar, Fumihiko Kimura, Kwang Woo Ahn, Zhen-Huan Hu, Yachiyo Kuwatsuka, John P Klein, Marcelo Pasquini, Koichi Miyamura, Koji Kato, Ayami Yoshimi, Yoshihiro Inamoto, Tatsuo Ichinohe, William Allen Wood, Baldeep Wirk, Matthew Seftel, Philip Rowlings, David I Marks, Kirk R Schultz, Vikas Gupta, Laurence Dedeken Show all

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | ELSEVIER SCIENCE INC | Published : 2016

Abstract

Bone marrow (BM) is the preferred graft source for hematopoietic stem cell transplantation (HSCT) in severe aplastic anemia (SAA) compared with mobilized peripheral blood stem cells (PBSCs). We hypothesized that this recommendation may not apply to those regions where patients present later in their disease course, with heavier transfusion load and with higher graft failure rates. Patients with SAA who received HSCT from an HLA-matched sibling donor from 1995 to 2009 and reported to the Center for International Blood and Marrow Transplant Research or the Japan Society for Hematopoietic Cell Transplantation were analyzed. The study population was categorized by gross national income per capit..

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