Journal article

The metabotropic glutamate 5 receptor is necessary for extinction of cocaine-associated cues

CJ Perry, F Reed, IC Zbukvic, JH Kim, AJ Lawrence

British Journal of Pharmacology | Published : 2016

Abstract

Background and Purpose There is currently no medication approved specifically to treat cocaine addiction. Behavioural interventions such as cue exposure therapy (CET) rely heavily on new learning. Antagonism of the metabotropic glutamate 5 (mGlu5) receptor has emerged as a potential treatment, by reducing the reinforcing properties of cocaine. However, mGlu5 receptor activity is necessary for learning; therefore, such agents could interfere with behavioural treatments. We used a novel rodent model of CET to test the effects of mGlu5 negative and positive allosteric modulators (NAM and PAM) on behavioural therapy. Experimental Approach Rats were trained to press a lever for cocaine in the pre..

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University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council


Funding Acknowledgements

Thanks to the Florey Core Animal Services for assistance with animal housing and maintenance. This research was funded by the National Health and Medical Research Council project grant 1022201 and the Victorian State Government Operational Infrastructure Scheme. Equipment was supported by a philanthropic grant from the Eric Ormond Baker Foundation.