Journal article

Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2

Yu-Ching Cheng, Tara M Stanne, Anne-Katrin Giese, Weang Kee Ho, Matthew Traylor, Philippe Amouyel, Elizabeth G Holliday, Rainer Malik, Huichun Xu, Steven J Kittner, John W Cole, Jeffrey R O'Connell, John Danesh, Asif Rasheed, Wei Zhao, Stefan Engelter, Caspar Grond-Ginsbach, Yoichiro Kamatani, Mark Lathrop, Didier Leys Show all

STROKE | LIPPINCOTT WILLIAMS & WILKINS | Published : 2016

Abstract

BACKGROUND AND PURPOSE: Although a genetic contribution to ischemic stroke is well recognized, only a handful of stroke loci have been identified by large-scale genetic association studies to date. Hypothesizing that genetic effects might be stronger for early- versus late-onset stroke, we conducted a 2-stage meta-analysis of genome-wide association studies, focusing on stroke cases with an age of onset <60 years. METHODS: The discovery stage of our genome-wide association studies included 4505 cases and 21 968 controls of European, South-Asian, and African ancestry, drawn from 6 studies. In Stage 2, we selected the lead genetic variants at loci with association P<5×10(-6) and performed in s..

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Grants

Awarded by DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS


Awarded by NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Awarded by NATIONAL HUMAN GENOME RESEARCH INSTITUTE


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE


Awarded by NATIONAL INSTITUTE ON AGING


Awarded by British Heart Foundation


Awarded by Medical Research Council


Awarded by National Institute for Health Research


Funding Acknowledgements

Drs Kittner, Longstreth, and Worrall are supported by research grants from National Institutes of Health (NIH). Dr Worrall is Deputy Editor for AAN/Neurology. Dr Cole is supported by a research grant from the Department of Veterans Affairs. Dr Boncoraglio is supported by a research grant from the Fondazione IRCCS Istituto Neurologico Carlo Besta. Dr Metso is supported by grants from the Finnish Medical Foundation, the Orion Farmos Research Foundation, the Maud Kuistila Memorial Foundation, and the Emil Aaltonen Foundation. Dr Danesh serves on advisory boards for Novartis, Merck Sharp & Dohme UK, Sanofi, the Medical Research Council, and Wellcome Trust and is a consultant for Takeda. The other authors report no conflicts.