Journal article
Monotherapy with Levetiracetam Versus Older AEDs: A Randomized Comparative Trial of Effects on Bone Health
T Hakami, TJ O’Brien, SJ Petty, M Sakellarides, J Christie, S Kantor, M Todaro, A Gorelik, MJ Seibel, R Yerra, JD Wark
Calcified Tissue International | Published : 2016
Abstract
Long-term anti-epileptic drug (AED) therapy is associated with increased fracture risk. This study tested whether substituting the newer AED levetiracetam has less adverse effects on bone than older AEDs. An open-label randomized comparative trial. Participants had “failed” initial monotherapy for partial epilepsy and were randomized to substitution monotherapy with levetiracetam or an older AED (carbamazepine or valproate sodium). Bone health assessments, performed at 3 and 15 months, included areal bone mineral density (aBMD) and content at lumbar spine (LS), total hip (TH), forearm (FA), and femoral neck (FN), radial and tibial peripheral quantitative computed tomography and serum bone tu..
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Funding Acknowledgements
This was an investigator-initiated study partly funded by UCB Pharma. UCB Pharma had no role in the study design, data collection, analysis, interpretation of data, nor in the preparation of this article. All authors had full access to the data. The corresponding author had full access to the data and had final responsibility for the decision to submit for publication.