Perforin facilitates beta cell killing and regulates autoreactive CD8( ) T-cell responses to antigen in mouse models of type 1 diabetes
Prerak Trivedi, Kate L Graham, Balasubramaninan Krishnamurthy, Stacey Fynch, Robyn M Slattery, Thomas Wh Kay, Helen E Thomas
Immunology & Cell Biology | WILEY | Published : 2016
Awarded by National Health and Medical Research Council of Australia (NHMRC)
We thank Dr P Santamaria (University of Calgary) for NOD8.3 mice, L Elkerbout, S Thorburn, E Tanuwidjaya, E Duff (St Vincent's Institute) for technical support, genotyping and animal husbandry and Dr M Jenkins (Peter MacCallum Cancer Centre) for critical reading. This work was funded by a National Health and Medical Research Council of Australia (NHMRC) Program grant (APP1037321) and fellowships from the NHMRC (HET) and JDRF (BK). The St Vincent's Institute receives support from the Operational Infrastructure Support Scheme of the Government of Victoria.