Journal article
Progression of HPV infection to detectable cervical lesions or clearance in adult women: Analysis of the control arm of the VIVIANE study
S Rachel Skinner, Cosette M Wheeler, Barbara Romanowski, Xavier Castellsague, Eduardo Lazcano-Ponce, M Rowena Del Rosario-Raymundo, Carlos Vallejos, Galina Minkina, Daniel Pereira Da Silva, Shelly McNeil, Vera Prilepskaya, Irina Gogotadze, Deborah Money, Suzanne M Garland, Viktor Romanenko, Diane M Harper, Myron J Levin, Archana Chatterjee, Brecht Geeraerts, Frank Struyf Show all
INTERNATIONAL JOURNAL OF CANCER | WILEY | Published : 2016
DOI: 10.1002/ijc.29971
Abstract
The control arm of the phase III VIVIANE (Human PapillomaVIrus: Vaccine Immunogenicity ANd Efficacy; NCT00294047) study in women >25 years was studied to assess risk of progression from cervical HPV infection to detectable cervical intraepithelial neoplasia (CIN). The risk of detecting CIN associated with the same HPV type as the reference infection was analysed using Kaplan-Meier and multivariable Cox models. Infections were categorised depending upon persistence as 6-month persistent infection (6MPI) or infection of any duration. The 4-year interim analysis included 2,838 women, of whom 1,073 (37.8%) experienced 2,615 infections of any duration and 708 (24.9%) experienced 1,130 6MPIs. Infe..
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Funding Acknowledgements
Grant sponsor: GlaxoSmithKline Biologicals SA