Journal article
Kawasaki disease and cardiovascular risk: a comprehensive review of subclinical vascular changes in the longer term
KYH Chen, N Curtis, N Dahdah, R Kowalski, M Cheung, DP Burgner
Acta paediatrica (Oslo, Norway : 1992) | Published : 2016
DOI: 10.1111/apa.13367
Abstract
©2016 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd. UNLABELLED: Studies of subclinical vascular changes post-Kawasaki disease indicate that, in general, individuals with a history of coronary artery aneurysms have increased carotid intima-media thickness, evidence of endothelial dysfunction, and increased arterial stiffness, possibly indicative of heightened cardiovascular risk. The results are less consistent for low-risk groups. CONCLUSION: Until data are available from larger prospective studies, it is prudent to advise families of individuals with a history of Kawasaki disease to minimise traditional modifiable cardiovascular risk factors.
Grants
Awarded by National Health and Medical Research Senior Research Fellowship
Awarded by National Heart Foundation Future Leader Fellowship
Funding Acknowledgements
KYHC holds an Australia Postgraduate Award scholarship from The University of Melbourne and a Postgraduate Health Research Scholarship from Murdoch Childrens Research Institute. DPB holds a National Health and Medical Research Senior Research Fellowship (APP1064629) and an honorary National Heart Foundation Future Leader Fellowship (100369). Research at Murdoch Childrens Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program. The Heart Research Group is supported by The RCH1000, The Royal Children's Hospital Foundation and Big W. The sponsors had no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; preparation, review or approval of the manuscript; and decision to submit the manuscript for publication.