Journal article

Pontine and cerebral atrophy in Lennox-Gastaut syndrome

Benjamin JC Newham, Evan K Curwood, Graeme D Jackson, John S Archer



OBJECTIVES: Lennox-Gastaut syndrome (LGS) is a severe epilepsy of childhood onset associated with intellectual disability and multiple seizure types. Characteristic interictal electrographic discharges include generalized paroxysmal fast activity and slow spike and wave, which we have previously shown recruit widespread areas of association cortex. We wished to determine whether patients with Lennox-Gastaut syndrome (LGS) have changes in cerebral volumes that match this pattern of cortical recruitment. METHODS: High resolution T1 weighted structural MRI was collected from 10 patients with LGS and 10 age and sex matched controls. Voxel-based morphometry (VBM) was used to compare tissue volume..

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Awarded by National Health and Medical Research Council (NHMRC) of Australia

Awarded by NHMRC

Funding Acknowledgements

This study was supported by the National Health and Medical Research Council (NHMRC) of Australia (project grant 628725; program grant 628952), and the Victorian Government Operational Infrastructure Support Program. G.D. Jackson is supported by an NHMRC practitioner fellowship (1060312). We would also like to acknowledge Mr Aaron Warren for his help conducting the study.