Journal article
Granulocyte colony-stimulating factor (G-CSF) plays an important role in immune complex-mediated arthritis
AD Christensen, C Haase, AD Cook, JA Hamilton
European Journal of Immunology | WILEY | Published : 2016
Abstract
Neutrophils are an abundant cell type in many chronic inflammatory diseases such as rheumatoid arthritis (RA); however, their contribution to the pathology of RA has not been widely studied. A key cytokine involved in neutrophil development and function is granulocyte-colony stimulating factor (G-CSF). In this study we used the K/BxN serum-transfer arthritis (STA) model, mimicking the effector phase of RA, to investigate the importance of G-CSF in arthritis development and its relation to neutrophils. Here, we show for the first time in this model that G-CSF levels are increased both in the serum and in inflamed paws of arthritic mice and importantly that G-CSF blockade leads to a profound r..
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Funding Acknowledgements
The authors wish to thank Melody Chang, University of Melbourne, for assistance with the animal work and Cynthia Louis, University of Melbourne, for assistance with the FACS analysis. The research is the result of a PhD project funded by the Novo Nordisk & Life In Vivo Pharmacology Centre (LIFEPHARM), Denmark (to A.D. Christensen). C.H. is employed by Novo Nordisk A/S. This work was also supported by a Senior Principal Research Fellowship (to J.A.H.) and a Project Grant (to A.D. Cook) from the National Health and Medical Research Council of Australia.