Journal article
Evidence for the recruitment of autophagic vesicles in human brain after stroke
T Frugier, JM Taylor, C McLean, N Bye, PM Beart, RJ Devenish, PJ Crack
Neurochemistry International | Published : 2016
Abstract
Autophagy is a homeostatic process for recycling proteins and organelles that is increasingly being proposed as a therapeutic target for acute and chronic neurodegenerative diseases, including stroke. Confirmation that autophagy is present in the human brain after stroke is imperative before prospective therapies can begin the translational process into clinical trials. Our current study using human post-mortem tissue observed an increase in staining in microtubule-associated protein 1 light chain 3 (LC3), sequestosome 1 (SQSTM1; also known as p62) and the increased appearance of autophagic vesicles after stroke. These data confirm that alterations in autophagy take place in the human brain ..
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Funding Acknowledgements
PJC and PMB are funded by the Australian Research Council (Future Fellowship) and National Health and Medical Research Council (Australia), respectively. Post-mortem brain tissues were received from the Victorian Brain Bank Network, supported by The Florey Institute of Neuroscience and Mental Health, The Alfred and the Victorian Forensic Institute of Medicine and funded by the National Health and Medical Research Council (Australia) and Parkinson's Victoria. The Florey Institute of Neuroscience and Mental Health receives infrastructure support from the Victorian State Government (Australia).