Metformin as a prevention and treatment for preeclampsia: Effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction

FC Brownfoot; R Hastie; NJ Hannan; P Cannon; L Tuohey; LJ Parry; S Senadheera; SE Illanes; TJ Kaitu'U-Lino; S Tong

Journal article

Metformin as a prevention and treatment for preeclampsia: Effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction

FC Brownfoot, R Hastie, NJ Hannan, P Cannon, L Tuohey, LJ Parry, S Senadheera, SE Illanes, TJ Kaitu'U-Lino, S Tong

American Journal of Obstetrics and Gynecology | Published : 2016

DOI: 10.1016/j.ajog.2015.12.019

Abstract

Background Preeclampsia is associated with placental ischemia/hypoxia and secretion of soluble fms-like tyrosine kinase 1 and soluble endoglin into the maternal circulation. This causes widespread endothelial dysfunction that manifests clinically as hypertension and multisystem organ injury. Recently, small molecule inhibitors of hypoxic inducible factor 1α have been found to reduce soluble fms-like tyrosine kinase 1 and soluble endoglin secretion. However, their safety profile in pregnancy is unknown. Metformin is safe in pregnancy and is also reported to inhibit hypoxic inducible factor 1α by reducing mitochondrial electron transport chain activity. Objective The purposes of this study wer..

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University of Melbourne Researchers

Fiona Brownfoot Author

Natalie Hannan Author

Ping Cannon Author

Tu'uhevaha Kaitu'u-Lino Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

Supported by The National Health and Medical Research Council of Australia (NHMRC; #1048707, #1046484, #1101871) and an Arthur Wilson RANZCOG scholarship; by an Australian Postgraduate Award and an AVANT scholarship (F.B); by a CR Roper Research Fellowship (N.J.R.); the NHMRC provided salary support (#1050765 [S.T.]; #1062418 [T.K.L.]; #628549 [S.S.]). The funders had no role in study design, data collection, analysis, decision to publish or the preparation of the manuscript.