Journal article
No evidence of a common DNA variant profile specific to world class endurance athletes
T Rankinen, N Fuku, B Wolfarth, G Wang, MA Sarzynski, DG Alexeev, II Ahmetov, MR Boulay, P Cieszczyk, N Eynon, ML Filipenko, FC Garton, EV Generozov, VM Govorun, PJ Houweling, T Kawahara, ES Kostryukova, NA Kulemin, AK Larin, A Maciejewska-Karlowska Show all
Plos One | Published : 2016
Abstract
There are strong genetic components to cardiorespiratory fitness and its response to exercise training. It would be useful to understand the differences in the genomic profile of highly trained endurance athletes of world class caliber and sedentary controls. An international consortium (GAMES) was established in order to compare elite endurance athletes and ethnicity- matched controls in a case-control study design. Genome-wide association studies were undertaken on two cohorts of elite endurance athletes and controls (GENATHLETE and Japanese endurance runners), from which a panel of 45 promising markers was identified. These markers were tested for replication in seven additional cohorts o..
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Awarded by Japan Society for the Promotion of Science
Funding Acknowledgements
Partial funding for the study has been received from the Prince Faisal Prize awarded to Drs. C. Bouchard, T. Rankinen, M. Sarzynski and B. Wolfahrt. CB is partially funded by the John W. Barton Jr Chair in Genetics and Nutrition. The study in Russia was supported by a grant from the Federal Medical-Biological Agency ("Sportgen project"), http://fmbaros.ru/en/fmba/infor/. The Spanish group (AL, CAM, CS, TY) was funded by Fondo de Investigaciones Sanitarias (grant # PI12/00914). Research in sports genetics to A. Lucia in Spain was funded by grants from the Consejo Superior de Deportes (CSD). This work in Japan was supported in part by grants from the programs Grants-in-Aid for Challenging Exploratory Research (24650414 to NF) from the Ministry of Education, Culture, Sports, Science and Technology; and by a grant-in-aid for scientific research from the Ministry of Health, Labor, and Welfare of Japan (to MM). No specific funding for this work was received for the studies performed in Australia, Poland, Kenya and Ethiopia. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.