Analysis of the ACTN3 heterozygous genotype suggests that alpha-actinin-3 controls sarcomeric composition and muscle function in a dose-dependent fashion
Marshall W Hogarth, Fleur C Garton, Peter J Houweling, Taru Tukiainen, Monkol Lek, Daniel G Macarthur, Jane T Seto, Kate GR Quinlan, Nan Yang, Stewart I Head, Kathryn N North
Human Molecular Genetics | OXFORD UNIV PRESS | Published : 2016
Awarded by National Health and Medical Research Council of Australia
Awarded by GTEx Laboratory, Data Analysis, and Coordinating Center (LDACC)
Awarded by National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health
This project was funded by grants from the National Health and Medical Research Council of Australia (1002033 and 1062500). The Genotype-Tissue Expression (GTEx) Project was supported by the Common Fund of the Office of the Director of the National Institutes of Health. The work by TT and DGM was partially funded by the GTEx Laboratory, Data Analysis, and Coordinating Center (LDACC) contract (HHSN268201000029C) to The Broad Institute, Inc. The work by M.L. and D.G.M. was partially funded by the National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health, under award R01GM104371. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.