Journal article

Cardiorespiratory fitness and risk of type 2 diabetes mellitus: A 23-year cohort study and a meta-analysis of prospective studies

Francesco Zaccardi, Gary O'Donovan, David R Webb, Thomas Yates, Sudhir Kurl, Kamlesh Khunti, Melanie J Davies, Jari A Laukkanen



AIMS: To investigate the association between cardiorespiratory fitness (CRF) and type 2 diabetes mellitus (T2DM) in a cohort of middle-age Finnish men and to summarise the current evidence in a meta-analysis of prospective studies. METHODS: CRF was measured at baseline in a random population-based sample of 2520 subjects by assessing oxygen uptake during maximal exercise. Cox regression analysis was used to estimate the association between CRF, expressed as metabolic equivalents (METs), and the risk of T2DM adjusted for potential confounders; this estimate was then pooled with the results of other prospective studies in a meta-analysis. RESULTS: Mean (SD) baseline age and CRF were 53 (5) yea..

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University of Melbourne Researchers


Funding Acknowledgements

FZ is a Clinical Research Fellow funded by Sanofi-Aventis. The research was supported by the National Institute for Health Research (NIHR) Diet, Lifestyle & Physical Activity Biomedical Research Unit based at University Hospitals of Leicester and Loughborough University; the NIHR CLARHC East Midlands; and the Finnish Foundation for Cardiovascular Research, Helsinki, Finland. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health.