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Humanized immune system (HIS) mice as a tool to study human NK cell development

ND Huntington, JP Di Santo, T Nomura, T Watanabe, S Habu

Current Topics in Microbiology and Immunology | SPRINGER-VERLAG BERLIN | Published : 2008

Abstract

The study of human hematopoiesis is conditioned by access to nondiseased human tissue samples that harbor the cellular substrates for this developmental process. Technical and ethical concerns limit the availability to tissues derived from the fetal and newborn periods, while adult samples are generally restricted to peripheral blood. Access to a small animal model that faithfully recapitulates the process of human hematopoiesis would provide an important tool. Natural killer (NK) cells comprise between 10% and 15% of human peripheral blood lymphocytes and appear conserved in several species. NK cells are implicated in the recognition of pathogen-infected cells and in the clearance of certai..

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