Journal article

The magnitude and encephalogenic potential of autoimmune response to MOG is enhanced in MOG deficient mice

D Linares, P Mana, M Goodyear, AM Chow, C Clavarino, ND Huntington, L Barnett, F Koentgen, R Tomioka, CCA Bernard, M Freire-Garabal, HH Reid

Journal of Autoimmunity | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2003


Myelin oligodendrocyte glycoprotein (MOG) is a minor component of central nervous system myelin presumably implicated in the pathogenesis of Multiple Sclerosis (MS). Immunization with MOG leads to the development of Experimental Autoimmune Encephalomyelitis (EAE), the experimental model of MS. It has been suggested that its encephalitogenic potential may be due to the lack of MOG self-immune tolerance. To clarify this, we have generated a MOG deficient mouse (MOG(-/-)) strain. Surprisingly, MOG(35-55)specific proliferation and Th1-type cytokine production were markedly enhanced in MOG(-/-)mice compared to wild type control. Furthermore, adoptive transfer of MOG(35-55)specific T cells, isolat..

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